DaburGenoprotective and Cellular Defence Support against Oxidative and Genotoxic Stress
To evaluate the genoprotective effect of Chyawanprash Awaleha (Dabur) against tobacco-smoke-associated genetic/cytogenetic damage in male bidi smokers.
Cytogenetic parameters after 2 months
4 of 4
parameters reduced · MI · CA · SCE · SA · P < 0.01 versus unsupplemented bidi smokers
25
Male bidi smokers
25
Matched for age, sex and social status
20 g twice daily
Dabur Chyawanprash Awaleha
2 months
Method
The study included 25 male bidi smokers, and 25 individuals matched with regard to age, sex and social status constituted the control population. The bidi smokers were given 20 g Dabur Chyawanprash Awaleha twice daily for 2 months.
Cytogenetic parameters were assessed, including mitotic index (MI), chromosomal aberrations (CA), sister chromatid exchanges (SCE), and satellite associations (SA), and results in DCP-treated smokers were compared with bidi smokers without CP supplementation.
Parameters assessed
- Mitotic index, MI
- Chromosomal aberrations, CA
- Sister chromatid exchanges, SCE
- Satellite associations, SA
Genotoxicity markers on somatic chromosomes: assessment of DNA damage, chromosomal aberrations and related genotoxic indices.
Cytogenetic findings after 2 months
| Parameter | After DCP | Matched controls |
|---|---|---|
| Chromosomal aberration frequency | 1.00 | 0.88 |
| Mitotic index, MI | Reduced, P < 0.01 | Reference |
| Sister chromatid exchanges, SCE | Reduced, P < 0.01 | Reference |
| Satellite associations, SA | Reduced, P < 0.01 | Reference |
After 2 months of Chyawanprash supplementation, all evaluated cytogenetic parameters showed a statistically significant decrease (p < 0.01) compared with bidi smokers without supplementation. The frequency of CA (1.00) reduces to the level of controls (0.88), indicating that Chyawanprash can minimise the genotoxic risk caused by mutagenic agents present in tobacco smoke. The study interpreted these findings as evidence of reduced cytogenetic/genotoxic effects associated with tobacco-smoke exposure.
Conclusion and scope
Dabur Chyawanprash Awaleha demonstrated genoprotective potential in bidi smokers, as evidenced by reductions in chromosomal aberrations, sister chromatid exchanges, satellite associations, and related cytogenetic parameters. The findings suggest that Chyawanprash may help minimize cellular/genetic damage associated with tobacco-smoke exposure. The cytogenetic findings should be interpreted as evidence of genoprotective potential and not as evidence of prevention or treatment of smoking-related disease.
ScopeThe findings provide preliminary support for a genoprotective effect but should not be extrapolated to claims of prevention or treatment of tobacco-related diseases.
Consumer-benefit reading
The findings support positioning Chyawanprash as providing support for cellular defence and maintenance of genomic integrity in the presence of oxidative and genotoxic stress. The evidence is relevant to cellular protection mechanisms rather than to the prevention or treatment of smoking-related disease.
Permissible consumer-facing claim language
- Supports the body's natural cellular defence against oxidative and genotoxic stress.
- Provides antioxidant and cellular protection support.
- Helps support cellular defence against oxidative stress.
- Supports natural mechanisms that help protect cellular and genetic integrity.
- Helps maintain cellular health in response to oxidative stress.
MI, mitotic index. CA, chromosomal aberrations. SCE, sister chromatid exchanges. SA, satellite associations. DCP, Dabur Chyawanprash. Source: Yadav JS, Thakur S, Chadha P. Chyawanprash Awaleha, a genoprotective agent for bidi smokers. Int J Hum Genet. 2003;3:33-38.
Dabur Chyawanprash Awaleha demonstrated genoprotective potential in bidi smokers across all four cytogenetic parameters assessed.
- Reductions were recorded in chromosomal aberrations, sister chromatid exchanges, satellite associations and mitotic index after two months of supplementation.
- The findings suggest Chyawanprash may help minimise cellular and genetic damage associated with tobacco-smoke exposure.